weight loss after stopping methimazole

Answer: The absence or discontinuation of antithyroid medications will produce unbelievable and undesirable effects. This is not a complete list of side effects and others may occur. No wonder so many people seem to be talking about Ozempic, an injectable drug approved by the . As a result of stopping her medication, she had developed thyroid storm, a life-threatening condition in which body temperature, heart rate, and blood pressure can rise to dangerous levels . Answer: The most effective treatment for Hyperthyroidism is completely blocking the thyroid glands. Methimazole, the main reason for increasing weight during treatment of Hyperthyroidism, causes about 10% of patients to gain weight during and after the treatment. Two weeks after stopping methimazole (on admission to the hospital) Two months after stopping methimazole; TSH: 0.35-4.94 <0.005: 0.0001 <0.0005: Free T 4: 0.7-1.48 ng/dl: 2.6 . Thus, it is considered a thyroid blocking agent. Question: How much weight did patients gain on using Methimazole? Available for Android and iOS devices. Foods to Avoid if you Have Thyroid Problems: Ive found that these 10 foods cause the most problems for thyroid patients. Advertising revenue supports our not-for-profit mission. It may be tempting to opt for a therapy such as having your thyroid removed or getting radioactive iodine ablation to treat your hyperthyroidism but these options are not necessarily better. Methimazole can pass into breast milk and may harm a nursing baby. One of the frequently used medications for hyperthyroidism is methimazole. Patient does not provide medical advice, diagnosis or treatment. This is all well and good but you have to realize a few very important points: #1. This thyroid hormone, released from the thyroid gland, causes the activation of thyroid hormone receptors in the body. and I'm proud to say that over 80,000+ people have used them over the last 7 years. Blood and urine cultures were negative. (former Osteopathic Physician). Terms of Use. (6) showed that muscle damage in eosinophilic myositis is mediated by local accumulation of eosinophils and subsequent production of interleukin 5. It also blocks the peripheral activation of T4 to T3 in your tissues reducing the amount of circulating and active T3 thyroid hormone. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Some of the more frequently reported adverse reactions have included skin rash, urticaria, nausea, loss of taste, and abnormal loss of hair. The dose of methimazole for adults ranges from 5 to 40 mg by mouth per day depending on how severe your hyperthyroidism is. Patient information was obtained from Thyroid Clinic Database at the University Hospitals Birmingham NHS Foundation Trust. All rights reserved. Cases of myositis were described with thionamides in which there was an immune-mediated mechanism, with either drug-induced lupus (7) (8) or ANCA-positive vasculitis (9). New York Times: A Healthy Mix of Rest and Motion. Methimazole is dose-dependent and acts differently in each person. I am also 1 month into zero carb diet, and all I got was stop gaining weight. redness of the face, neck, arms, and occasionally, upper chest. So we know that this is not an isolated phenomenon, but how can it be? This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector. So far, myositis secondary to carbimazole was described in the context of a lupus-like syndrome or other rare cases of anti-neutrophil cytoplasmic antibodies-associated vasculitis. We do not endorse non-Cleveland Clinic products or services. If you have had your thyroid removed or if you underwent radioactive iodine ablation then you will have a more difficult time losing weight when compared to someone who is taking methimazole or PTU. Four months after his last visit, the patient remains symptom free. Hi, I also put on weight over the almost three years I took carbimazole. It may not cover all possible information. Store at room temperature away from moisture and heat. Restart Medical LLC. Although not all of these side effects may occur, if they do occur they may need medical attention. There were 1373 patients, 573 were treated with antithyroid medications and 800 were treated with RAI or a combination. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. Unusual weakness or fatigue, fever, headache, skin rash, muscle or joint pain, loss of appetite, pain, tingling, or numbness in the hands or feet. Egton Medical Information Systems Limited. Yes, I know. These three factors are important in understanding how methimazole can lead to weight gain in certain people. It would be better to take preventative measures to avoid such a situation. Engage in high-intensity interval training to melt layers of fat. Prior to starting medication, I had always had a pretty fast metabolism and my weight was in the 105-115 range for most of my adult life (Im 51 and have a slight frame, so this was a normal weight for me). Methimazole, as you probably already know if you are taking it, is a medication that is designed to treat hyperthyroidism. Before treatment patients with hyperthyroidism weighed less than the comparison group. These side effects may go away during treatment as your body adjusts to the medicine. That's why I asked. Perform strength training three to four days per week to build muscle. It may be possible to manage these symptoms by taking a close look at your dose and altering your dose if that makes sense. Hi! Last updated on Jan 5, 2023. At the time of conception, her mother was receiving therapy for Graves' disease with methimazole 20 mg daily. When optimizing thyroid function make sure you shoot for the optimal lab tests which you can find here. Some side effects may occur that usually do not need medical attention. Do not treat yourself. and transmitted securely. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. NOTE: This sheet is a summary. Step 1 Consult your physician before starting to restrict calories. Graves disease: the most common cause of hyperthyroidism in the United States. Swelling at the base of the neck can occur if your thyroid gland (goiter) is enlarged. effects. Similarly, the ANCA were negative and the muscle biopsy did not show vasculitis. I felt good for two more moths with my normal weight until suddenly 4 weeks ago I started loosing weight agin. This study showed that among 42 patients with Graves disease that the average weight gain was around 12 pounds after starting methimazole. Mary Frances McCullar in November 2022 (left) and in April 2023. King Pharmaceuticals Inc (2001): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Usual Pediatric Dose for Hyperthyroidism: Initial dose: 0.4 mg/kg orally per dayMaintenance dose: 0.2 mg/kg orally per day (approximately half the initial dose) Comments: Daily doses are usually given in 3 divided doses at approximately 8 hour intervals. Take the missed dose as soon as you remember. #2. Talk to your care team about the use of this medication in children. These side effects may go away during treatment as your body adjusts to the medicine. +1(415)-323-0836 (Whatsapps), [emailprotected], Weight Loss After Reducing Use Of Methimazole, 2019 - 2022 wholesomealive.com. Other studies have shown that after hyperthyroidism treatment patients have a 32% increased risk of obesity and most of this weight gain occurs in the first 2 years after therapy (9). And if it is along with weakness, fever, sleeping problems, or changes in bowel habits, we recommend that you consult your doctor. National Library of Medicine red skin lesions, often with a purple center. It does this by blocking an enzyme known as thyroid peroxidase(3) which is responsible for producing thyroid hormone. A Community for those living with and dealing with Graves' Disease. Some related it to a direct effect of carbimazole on muscle (5) and others related it to a rapid decrease in thyroid hormones resulting in a relative local hypothyroid state within the muscle, which may contribute to the creatine phosphokinase elevation (5). Patient is a UK registered trade mark. Has this happened to anyone else? You may report side effects to FDA at 1-800-FDA-1088. Exercise regularly. A total of 65% of patients gained 5% of their weight and 38% gained 10% or more. P.S. If you are post-thyroidectomy (meaning you dont have a thyroid) then its best to look at your current dose of thyroid medication and to optimize that dose to get your free T3 levels in a high enough range (you can read more here). A long journey of gradually reducing MMI dose did cut me back a bit on weight. The fever subsided. Therefore, if you feel hungry while taking Methimazole, you will eat more, leading to weight gain. Posted Home Patients Portal Clinical Thyroidology for the Public March 2020 Vol 13 Issue 3 p.3-4, Summaries for the Public from recent articles in Clinical Thyroidology Takiing Armour (thyroid hormone replacement) has seemed to cause your hyperthyroidism. The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported. Parasitic infections are among the most common differential diagnoses of eosinophilic myositis (Table 2). Learn which foods you should avoid if you have thyroid disease of any type. Musculoskeletal complaints are common in thyroid disorders and are also described as side effects to anti-thyroid drugs. You may cause more harm than good if you adjust your medication in this way. Has anyone experienced this ?. Follow the directions on the prescription label. Available for Android and iOS devices. Serology for trichinella, which is relatively more common than other parasites, was negative. Mayo Clinic College of Medicine and Science, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Graduate Medical Education, Mayo Clinic School of Continuous Professional Development, Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Financial Assistance Documents Minnesota, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, feeling of constant movement of self or surroundings, general feeling of discomfort, illness, or weakness, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, feet, or lower legs, swollen, painful, or tender lymph glands in the neck, armpit, or groin, pain or discomfort in the chest, upper stomach, or throat. Methimazole-induced myositis is a rare clinical entity. Its also widely believed that treating and managing hypothyroidism is easier when compared to hyperthyroidism. Get your prescription refilled before you run out of medicine completely. It has been shown in studies that all treatments for hyperthyroidism result in marked weight gain (8). I don't practice medicine anymore and instead specialize in helping people like YOU who have thyroid problems, hormone imbalances, and weight loss resistance. Are you suffering from weight gain while taking methimazole? Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. Unfortunately, the antinuclear antibodies were not available initially but an evaluation done later showed a low titer of 1/80. Torlinska B et al 2019 Patients treated for hyperthyroidism are at increased risk of becoming obese: findings from a large prospective secondary care cohort. Copyright 2023 Elsevier Inc. All Rights Reserved. Sign up to receive 20% off your first order. Other risk factors for more weight gain were Graves disease as the cause of the hyperthyroidism, an elevated TSH after treatment, or the requirement of thyroid hormone replacement. Eat dark green leafy vegetables like spinach and kale for a calcium boost. Methimazole prevents the thyroid gland from producing too much thyroid hormone. Most cases of agranulocytosis occur within the first 90 days of treatment, but this complication can occur even a year or more after starting therapy. Sometimes its best to go right to the source of the problem and get it taken out and never mind all these prescriptions if you can that is..Hope this helped and hope you get better soon , as I know how tough it is Methimazole is not a steroid. THE FULL ARTICLE TITLE feeling of constant movement of self or surroundings, general feeling of discomfort, illness, or weakness, sores, ulcers, or white spots on the lips or in the mouth, swelling of the face, feet, or lower legs, swollen, painful, or tender lymph glands in the neck, armpit, or groin, pain or discomfort in the chest, upper stomach, or throat. The site is secure. You may also find benefit in trying to reduce inflammation if your hyperthyroidism is caused by Graves disease (which is an autoimmune disease) with some strategies such as these. Do not take your medication more often than directed. Some items may interact with your medicine. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Two weeks after stopping methimazole, magnetic resonance imaging of the pelvis performed upon hospitalization showed evidence of myositis in the gluteus maximus muscles bilaterally, much more marked on the left, associated with fasciitis (Fig. . At my high point of GD, I was down to 124 and then gradually back up to 139 after starting MMI Now reducing to 3 x 2.5mg a week and I am happy to be 130. Table of Contents | PDF File for Saving and Printing, Treatment for hyperthyroidism increases the risk of obesity in some patients, Change In Thyroid Nodule Volume Calculator, Find an Endocrinology Thyroid Specialist, https://www.thyroid.org/thyroid-and-weight/, Clinical Thyroidology for the Public (CTFP). Studies have suggested that the risk of agranulocytosis is greater in older patients and that they have a higher rate of death. You may report them to the FDA. These side effects may go away during treatment as your body adjusts to the medicine. Your blood may need to be tested often. He was started on propranolol 60mg/day and methimazole 20mg/day. ABC7 Chicago 24/7 Stream. Hyperthyroidism (Overactive): https://www.thyroid.org/hyperthyroidism/, Graves Disease: https://www.thyroid.org/graves-disease/, Thyroid and Weight: https://www.thyroid.org/thyroid-and-weight/. If you have questions regarding your health you should seek qualified information from a medical professional or your doctor. In addition, it highlights the role of the interprofessional team . I cant fit into my clothes now, which is not a morale booster If anyone has any advice or a similar experience, Id love to hear it! [Ref], Very rare (less than 0.01%): Nephritis[Ref], Frequency not reported: Insulin autoimmune syndrome, Frequency not reported: Vertigo, drug fever[Ref]. Gained it back rather quickly after I got on methimazole. Magnetic resonance imaging of the pelvis. a beta blocker--atenolol, carvedilol, labetalol, metoprolol, nadolol, propranolol, sotalol, and others. For example, some can increase your appetite, while others can decrease it. Tapazole is a form of methimazole used to treat hyperthyroidism, a condition in which the thyroid gland produces excess thyroid hormone, according to MayoClinic.com. Learn more about methimazole, how it can cause weight gain, and how to lose weight if you have hyperthyroidism here: In order to understand how methimazole leads to weight gain (and yes, it can cause weight gain) we need to understand how it works in the body. You can take this medication with or without food. as being in breach of those terms. A second hypothesis is that Methimazoles sulfa moiety might have interaction. For more information, please see our It decreases the amount of thyroid hormone your body makes. #3. Having hyperthyroidism can cause an increase in your metabolism and sudden weight loss. In contrast, if your weight declines exponentially, you need to take it seriously because this type of weight loss is not suitable for your body. Methimazole can lower blood cells that help your body fight infections and help your blood to clot. You should seek emergency medical attention if you experience any of the following symptoms: hives; challenging breathing; lips, tongue, throat, or swelling of your face. Graves' disease was diagnosed . Teprotumumab (Tepezza). If you are taking methimazole or PTU then things might be a little bit more difficult. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Are there different degrees of thyroid suppression? Replacement therapy means the goal is a TSH in the normal range and is the usual therapy. Why do we observe weight loss after stopping Methimazole? Wholesomealive.com is reader-supported. He was started on propranolol 60 mg/day and methimazole 20 mg/day. Ive been really watching what I eat and exercising, and my weight hasnt budged. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. When we stop using it, our diet returns to normal, and weight loss is noticeable, and a sudden weight loss will lead to many other serious health concerns. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain chills cough dark urine difficulty in breathing dizziness or lightheadedness drowsiness feeling of constant movement of self or surroundings fever general feeling of discomfort, illness, or weakness headache hoarseness Inclusion in an NLM database does not imply endorsement of, or agreement with, Thyroid 29:13801389. Ive put on weight since starting methimazole two years ago. Theres also another very important point to consider: Doctors would prefer patients to be HYPOthyroid over being HYPERthyroid due to the side effects of hyperthyroidism. A small change in your dose may be sufficient to restore some thyroid function (without causing the symptoms of hyperthyroidism) which can help manage your weight. Among the possible treatments are: Methimazole is an antithyroid drug. However, you should always take it the same way to make sure the effects are the same. The symptoms resolved completely within 3 weeks. A woman took semaglutide after struggling to lose weight gained during the pandemic. Methimazole affects the production of thyroid hormone and is useful in treating conditions related to thyroid hormone, especially thyrotoxicosis. You may report side effects to FDA at 1-800-FDA-1088. In our case, the temporal relationship between the myositis and the introduction of methimazole cannot be ignored. Its been almost 2 mths now, and feel alot better with out taking as many pills . Sometimes this can even happen despite increased appetite. Hey There! When you experience contamination symptoms, such as: contact your health practitioner right away. So does it make sense that you can put someone on a thyroid blocker like methimazole and expect to perfectly balance thyroid hormone in the body? Not all possible interactions are listed in this medication guide. https://patient.info/forums/discuss/weight-loss-after-reduced-methimazole-dose--720406. Antibodies to double-stranded DNA are detectable in <5% of drug-induced lupus (7). Differential diagnosis of eosinophilic myositis. Methimazole Side Effects You Should Be Aware Of (What to Expect), Hashimotos vs Graves Disease: Differences & Similarities, read more about my own personal health journey, free thyroid downloads, resources, and PDFs here, The 5 Best Breads For Hashimotos Thyroiditis, 10 Hashimotos Facts That Every Patient Should Know, 8 Ways Hypothyroidism Can Change Your Face. Hyperthyroidism: a condition where the thyroid gland is overactive and produces too much thyroid hormone. Sometimes it may be possible to simply reduce your dosage which will allow some thyroid hormone activation and production in your body. I go to great lengths to help my users better understand their health; however, the content you see here is not a substitute for medical advice. [Ref], Frequency not reported: Lupus-like syndrome[Ref], Frequency not reported: Jaundice, hepatitis[Ref], Frequency not reported: Edema, periarteritis, A 5-year-old female experienced aplasia cutis congenita coincident with in utero exposure to methimazole. Hyperthyroid Symptoms Checklist Do you Have an Overactive Thyroid? Hello. I do agree with you for that MMI isn't a steroid. Emily Aboujaoude, Pharm.D., clinical assistant professor at the Rutgers University Ernest Mario School of Pharmacy, agrees. This can obviously be confusing for patients, but it doesnt have to be. #4. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you take these medications at the same time as your thyroid medication, it can interfere with how well it works. Aplasia cutis congenita has been reported as a possible teratogenic effect of methimazole therapy in multiple case reports. Your thyroid, when working properly, helps manage your weight. Successful treatment was either having normal thyroid hormone levels or requiring thyroid hormone replacement. Answer: The thyroid hormone interacts with many tissues in the body, including the brain, fat cells, muscle, liver, and pancreas. Both hyperthyroidism and methimazole are associated with myositis. I love to write and share what I've learned over the years. Other than anti-thyroid drugs, -blockers have also been implicated in a lupus-like reaction (7), but our patient had complete resolution of symptoms while he was still on -blockers. Has anyone experienced weight loss after reducing their methimazole dose? Eat fresh produce, whole grains, low fat dairy, lean beef, fish, eggs and soybeans to keep you feeling full while eating less. This risk is slightly higher with RAI therapy compared to medications. Before Methimazole can also, without delay, inhibit TPO. Careers, Unable to load your collection due to an error. Rapid clinical and laboratory improvements were evident. This is a great resource, I wish Id found it earlier! Methimazole may cause serious side effects. Gestational diabetes, high levels of blood sugar during pregnancy . BACKGROUND I had an issue too..the pills helped but the weight gain wasn't all that great. According to a study, almost 42 people gained about 12 pounds by blocking their thyroid glands. Copyright: Merative US L.P. 1973, 2023. I've lost weight gradually because I am more active, eat less and am aiming to lose the 16 lbs I put on when I was on the drug . Three months ago, in December my doctor had me reduce reduced dose to 10 mg. No problem, I felt good for two more months and maintaining with my normal weight until suddenly about 4 weeks ago I started losing weight again. I assumed once the medication was out of my system that my weight would normalize, but I feel like Im in a completely different body that doesnt respond the way it used to. Since Hyperthyroidism is treated with Methimazole, this is the leading cause of weight gain during treatment. Several differential diagnoses arise when managing a hyperthyroid patient with muscle complaints. This content does not have an Arabic version. 1). Reducing the dosage will not help that much, perhaps a little, but still a steroid and that's sometimes what they give patients that can not gain weight. This activity reviews methimazole's indications, interactions, adverse effects, and other pharmacodynamic and pharmacokinetic factors. Therefore, we raise the awareness regarding a rare side effect of methimazole: myositis. We report a patient with hyperthyroidism who, early after therapy with methimazole, developed hepatitis, eosinophilia, and fever that resolved completely after stopping the medication as well as a delayed onset of biopsy-proven eosinophilic myositis and fasciitis of gluteal muscles that resolved eventually without any additional therapy. Along with its needed effects, methimazole may cause some unwanted effects. Methimazole is an antithyroid medicine. At my high point of GD, I was down to 124 and then gradually back up to 139 after starting MMI. Take your doses at regular intervals. Hyperthyroidism weight gain after treatment is a common side effect. Your methimazole is a steroid I believe and it will make you got to the fridge alot more. government site. Maintaining the rate at which you digest fats and carbohydrates, controlling your body temperature. They need to know if you have any of these conditions: Take this medication by mouth with a glass of water. Our mission is to provide easy to read and in-depth medical information. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, Low blood counts, like low white cell counts, An unusual or allergic reaction to methimazole, other medications, foods, dyes, or preservatives, Certain medications for high blood pressure, heart disease, irregular heartbeat like metoprolol and propranolol, Allergic reactionsskin rash, itching, hives, swelling of the face, lips, tongue, or throat, Infectionfever, chills, cough, or sore throat, Liver injuryright upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue, Low thyroid levels (hypothyroidism)unusual weakness or fatigue, increased sensitivity to cold, constipation, hair loss, dry skin, weight gain, feelings of depression, Unusual weakness or fatigue, fever, headache, skin rash, muscle or joint pain, loss of appetite, pain, tingling, or numbness in the hands or feet. Basically, if your thyroid is blocked sufficiently then you may be burning fewer calories at rest when compared to normal healthy adults. Methimazole can also be used for functions no longer indexed on this remedy. Welcome to my website! Maintaining a healthy diet and staying active will aid in weight loss while you take Tapazole. appropriate medical assistance immediately. Its impossible to completely replicate this innate system in the body by taking thyroid hormone medication (though that shouldnt stop us from trying). Written informed consent was obtained from the patient/patient's mother for publication of this case report. Patients may regain the weight they had lost or may overshoot and become obese. This balance may be difficult to achieve with methimazole, but it is always worth attempting. "Sudden weight loss [by any means] is associated with a loss of . While this medication may be prescribed for children for selected conditions, precautions do apply. You should look at your dose in conjunction with your current physician and your lab tests. Hi! The average weight gain in these patients ranges from around 10-15 pounds or an increase of 8.49 in BMI (a huge increase!). Weight loss is possible while taking Tapazole if you have a strategy. In our case, the patient could have drug-induced lupus as shown by the positive anti-double-stranded DNA but the marked eosinophilia, the presence of eosinophilic myositis, and the absence of vasculitis on biopsy pointed toward a different mechanism responsible for the myositis than a simple drug-induced lupus. Undergoing treatment for hyperthyroidism can cause excessive weight gain. I am on 10mg Methimazole. 2). I have 8lbs more to lose and hope to achieve this by May 2020. TSH: thyroid stimulating hormone produced by the pituitary gland that regulates thyroid function; also the best screening test to determine if the thyroid is functioning normally. Since my diagnosis of hyper/graves almost 1.5 years ago, I've been on tapazole to control my levels. Three months ago, my doctor reduced dose to 10 mg. Never alter your dose without consulting with your physician first! pale skin, easy bruising, unusual bleeding. Some of the important ones are below: Stop using Methimazole before proper treatment: If you stop taking Methimazole before Hyperthyroidism is cured, you will lose a lot of weight. METHIMAZOLE (meth IM a zole) treats high thyroid levels (hyperthyroidism) in your body. The lack of proper medication will lead to myxoedema if the condition is hypothyroidism, and if the condition is hypothyroidism, then it will lead to a thyroid storm. Drug information provided by: Merative, Micromedex. Wholesomealive is an online healthcare media publishing website. Hyperthyroidism can cause thinning bones, states MayoClinic.com. Stop using methimazole and call your doctor right away if you have signs of infection such as: sudden weakness or ill feeling, fever, chills, sore throat, cold or flu symptoms; painful mouth sores, pain when swallowing, red or swollen gums; or.

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